Effects of Exercise on the Brain, Animation

Effects of Exercise on the Brain, Animation

(USMLE topics, neurology) Effect of aerobic exercise on cognitive functions, depression treatment, and neuroplasticity, mechanisms involved. This video is available for instant download licensing here : https://www.alilamedicalmedia.com/-/galleries/narrated-videos-by-topics/health-and-fitness/-/medias/cda1328b-3332-43e4-ba2d-04c5042ffe26-effects-of-exercise-on-the-brain-narrated-animation
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Voice by: Ashley Fleming
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Apart from body fitness, physical exercise also has beneficial effects on the brain. A regular routine of aerobic exercise can improve memory, thinking skills, moods; and have protective effects against aging, injuries and neurodegenerative disorders.
It is noteworthy that these effects are specific to “aerobic” exercise – the kind of exercise that accelerates heart rate and respiratory rate, such as running, cycling, swimming… Non-aerobic activities, such as stretching or muscle building, do not have the same effect. The effects appear to result from increased blood flow to the brain and subsequent increase in energy metabolism. A certain degree of intensity is required to achieve the beneficial outcome.
Aerobic exercise increases the production of several growth factors of the nervous tissue, known as neurotrophic factors, among which BDNF, for Brain-Derived Neurotrophic Factor, has a central role. BDNF exerts a protective effect on existing neurons, and stimulates formation of new neurons from neural stem cells in a process called neurogenesis.
BDNF appears to coordinate its action with at least 2 other growth factors: insulin-like growth factor 1, IGF-1, and vascular endothelial growth factor, VEGF, whose expression levels also increase following aerobic exercise. BDNF interacts with IGF-1 to induce neurogenesis, while VEGF stimulates growth of new blood vessels, a process known as angiogenesis. Together these processes improve survival of existing neurons, produce new brain tissue, and constitute the brain’s enhanced plasticity that underlies the exercise-induced protective effect against aging, degenerative diseases and injuries.
Changes in BDNF levels are observed throughout the brain but are most remarkable in the hippocampus, the area that is responsible for memory retention and learning. In fact, regular exercise has been shown to increase the size of the hippocampus and improve cognitive functions.
While acute exercise, defined as a single workout, can produce significant changes in BDNF levels and subsequent improvements in learning performance; a regular exercise program progressively increases BDNF baseline level and make its response steadier overtime. It appears that some cognitive functions are enhanced immediately after a single workout, while others only improve following a consistent exercise routine.
The immediate effect of acute exercise is most remarkable on the body’s affective state. A single bout of exercise can promote positive emotions, suppress negative feelings, reduce the body’s response to stress, and sometimes, after intense exercise, induce a euphoric state known as “runner’s high” sensation. These effects may persist for up to 24 hours, and are thought to result from exercise-induced upregulation of several neurotransmitters involved in mood modulation. These include:
– Dopamine – a neurotransmitter of the brain reward pathways;
– Serotonin, commonly known as the substance of well-being and happiness, whose low levels in the brain have been associated with depressive disorders;
– Beta-endorphin, or endogenous morphine, an endogenous opioid;
– and anandamide, an endogenous cannabinoid, a substance related to psychoactive chemicals in marijuana. Endogenous opioids and cannabinoids are involved in pain modulation, stress and anxiety reduction and are believed to underlie the “runner’s high” sensation.


  1. Alan W on December 21, 2021 at 3:42 pm

    I run from the police. No wonder I am so smart

  2. Ali Abdel Naeem on December 21, 2021 at 3:44 pm

    Woooooow,it is very important info for me as chess player get redy for master title thank you

  3. Salman Khan on December 21, 2021 at 3:45 pm


  4. red warrior on December 21, 2021 at 3:49 pm

    I’ve stopped running since I was in Middle School and I just don’t feel like I can do things and learn incredibly faster than others anymore. Thx for sharing this video! I’ll try more aerobic exercises from now on.

  5. Rehan shaikh on December 21, 2021 at 3:50 pm

    Sir, I have parkinson’s desease since childhood, how to treat it?

  6. Shaikh Aaves on December 21, 2021 at 3:51 pm

    That’s Amazing!!!!!

  7. Random Delirious on December 21, 2021 at 3:52 pm

    I run in cs:go

    Does that count as aerobic exercise?

  8. Ahmad The Aviation Lover on December 21, 2021 at 3:53 pm

    This is way too much information

  9. Xu Han on December 21, 2021 at 3:54 pm

    Wonderful!!! Thanks a lot!

  10. Ari Dochshanov on December 21, 2021 at 3:55 pm

    Yeah? After watching this video, I wondering why most of the bodybuilders are Stu p I d

  11. Sagiv Alia on December 21, 2021 at 3:56 pm

    Are the exercise types of jumping jacks, high knees and the such possess the same effects?
    They are sorta like I would name it a flexible intensity training.

  12. christianv80 on December 21, 2021 at 3:58 pm

    When I start to run or do long bikes I force myself during the beginning but after a couple miles I start feeling euphoric and motivated to keep going and feel amazing 💪

  13. Gunjan Jain on December 21, 2021 at 4:00 pm

    Thank you for this valuable knowledge. 😊

  14. DWNtoERTH on December 21, 2021 at 4:02 pm

    Is it correct to say that if I stand on my head then blood flow will increase to my brain and I can get the same results?

  15. Ali Abdel Naeem on December 21, 2021 at 4:05 pm

    Very nice video thanks

  16. Mohammad AL-kamsha on December 21, 2021 at 4:14 pm

    No wonder there is no dislikes 👍👍🖒🖒

  17. Julian Falciola on December 21, 2021 at 4:15 pm

    I wonder going for a walk a few times a day?

  18. Cisco Jr on December 21, 2021 at 4:15 pm

    I have fibromyalgia and going to the gym for treatment is the biggest reason why I’m the only one who’s not suicidal like others who suffer.

  19. Asim Moufaq on December 21, 2021 at 4:17 pm

    I like all of the video

  20. Kim Daniel on December 21, 2021 at 4:18 pm

    Me: I hate running…

    Me after watching this: I’m ready I’m ready I’m ready!!!!

  21. Pharmacy Supreme on December 21, 2021 at 4:21 pm

    I am from India and it is a very good video sir. I have one question please reply sir.
    During aerobic exercise what is the scientific reason which enhances the serotonin release in brain ?

  22. Yui San on December 21, 2021 at 4:26 pm

    I searched this after watch Baki training

  23. Talita Laurie on December 21, 2021 at 4:28 pm

    I like all of your videos!

  24. ant savs on December 21, 2021 at 4:28 pm

    I heard 20 minutes of exercise will have similar effects. Has anyone else heard of that?

  25. Judge Ady on December 21, 2021 at 4:38 pm

    Well, I certainly am ignorant right now.

  26. Alila Medical Media on December 21, 2021 at 4:38 pm

    Help us make more videos like this and get access to EXCLUSIVE videos plus other great rewards: https://www.patreon.com/AlilaMedicalMedia/posts